Elemental and mutational analysis of lung tissue in lung adenocarcinoma patients
نویسندگان
چکیده
منابع مشابه
The transcriptional landscape and mutational profile of lung adenocarcinoma.
All cancers harbor molecular alterations in their genomes. The transcriptional consequences of these somatic mutations have not yet been comprehensively explored in lung cancer. Here we present the first large scale RNA sequencing study of lung adenocarcinoma, demonstrating its power to identify somatic point mutations as well as transcriptional variants such as gene fusions, alternative splici...
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Lung adenocarcinoma patients of similar clinical stage and undergoing the same treatments often have marked interindividual variations in prognosis. These clinical discrepancies may be due to the genetic background modulating an individual's predisposition to fighting cancer. Herein, we hypothesized that the lung microenvironment, as reflected by its expression profile, may affect lung adenocar...
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Introduction: In radiation therapy of lung tumors, respiratory motion causes target moving, so a larger margin is needed to cover the clinical target volume (CTV). With the margin increasing, a larger volume of normal tissue will be exposed to high-dose. In this study, dosimetric parameters of normal lung tissue were compared between gated and conventional radiotherapy (RT), u...
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Pulmonary lymphangitic carcinomatosis is the spread of a tumor to the lungs through the lymphatic system, which is a rare and final manifestation of cancer with a poor prognosis. Its main symptom is gradual and progressive dyspnea. The method of choice for diagnosis is high-resolution CT (HRCT), the most common finding of which is an increase in nodular and irregular septal thickness between th...
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ژورنال
عنوان ژورنال: Translational Lung Cancer Research
سال: 2019
ISSN: 2218-6751,2218-6751
DOI: 10.21037/tlcr.2019.08.18